Most comprehensive direction that is given by Romans (6)
I believe the answer is:
widest
'most comprehensive direction that is given by romans' is the definition.
'widest' can be an answer for 'most comprehensive' (I've seen this in another clue). I am not sure about the rest of the definition.
'direction that is given by romans' is the wordplay.
I cannot quite see how this works, but
'direction' could be 'w' (W is an example) and 'w' is found within the answer.
'that is' could be 'idest' ('that is' in Latin) and 'idest' is present in the answer.
This accounts for all the letters.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for widest that I've seen before include "spread maximally" , "most unplayable for batsman?" , "most spacious" , "Most broad" , "Broadest" .)