Most important one holds paper sheets together (6)
I believe the answer is:
staple
'most important' is the definition.
'staple' can be an answer for 'important'. I'm not sure about the 'most' bit.
I cannot understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for staple that I've seen before include "Paper securer; main" , "security device" , "Paper pin for plates" , "Paper fastening" , "Basic commodity for which demand is constant" .)