Most importantly (5,3)
'most importantly' is the definition.
(of central importance)
This is the entire clue.
(Other definitions for centrally that I've seen before include "in the middle" , "Chiefly" .)
'most importantly' is the definition.
(synonyms)
This is the entire clue.
(Other definitions for above all that I've seen before include "primarily" , "Mainly" , "More than anything else" , "omnipotent?" , "First and foremost" .)