Crossword Genius

Most irritable clergyman grasps 1 + 100 + 1000 + 50 (10)

Ross

I believe the answer is:

prickliest

'most irritable' is the definition.

'clergyman grasps 1 100 1000 50' is the wordplay.
'clergyman' becomes 'priest' (priest is a kind of clergyman).
'grasps' indicates putting letters inside.
'c c00 c000 50' becomes 'ckli' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'priest' going around 'ckli' is 'PRICKLIEST'.

(Another definition for prickliest that I've seen is " with most needles?".)

I've seen this clue in The Guardian.
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