Most of all, smokers suffering from nonprofit venture (9)

I believe the answer is:

lossmaker

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'nonprofit venture' is the definition.
I don't know anything about this answer so I cannot judge whether this works.

'most of all smokers suffering' is the wordplay.
'most of' means to remove the last letter.
'suffering' indicates anagramming the letters.
'all' with its final letter taken away is 'al'.
'al'+'smokers'='alsmokers'
'alsmokers' with letters rearranged gives 'LOSSMAKER'.

'from' is the link.

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I've seen this clue in The Guardian.

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