Most of posse fighting with this nasty piece of work could be hopeless (4)
I believe the answer is:
heel
'most of posse fighting with this nasty piece of work could be hopeless' is the definition.
The definition suggests a singular noun which matches the answer.
This is all the clue.
Can you help me to learn more?
(Other definitions for heel that I've seen before include "Not the sole - scoundrel" , "Hindu loincloth" , "Untrustworthy person" , "Slang scoundrel or rear of foot" , "Crusty end of a loaf" .)