Most preferred, Freud and Van Eyck, primarily (4)
I believe the answer is:
fave
'most preferred' is the definition.
'fave' can be an answer for 'preferred' (short for favourite). I'm not sure about the 'most' bit.
'freud and van eyck primarily' is the wordplay.
'primarily' suggests taking the first letters.
The initial letters of 'freud and van eyck' is 'FAVE'.
Can you help me to learn more?
(Other definitions for fave that I've seen before include "Most popular" , "Best-loved" .)