Most unpleasant people, sneaks (6)
I believe the answer is:
creeps
'sneaks' is the definition.
('creep' can be a synonym of 'sneak')
I can't explain the remainder of the clue.
Can you help me to learn more?
(Other definitions for creeps that I've seen before include "Moves slowly - like servile people?" , "treads softly" , "Unpleasantly strange people" , "Crawls silently" , "'''Tomorrow, and tomorrow, and tomorrow, ... in this petty pace from day to day'' (Shakespeare) (6)'" .)