Most unpleasant wine brought into home (8)
I believe the answer is:
nastiest
'most unpleasant' is the definition.
('nasty' can be a synonym of 'unpleasant')
'wine brought into home' is the wordplay.
'wine' becomes 'asti' (I've seen this before).
'brought into' means one lot of letters goes inside another.
'home' becomes 'nest' (I've seen this before).
'asti' inserted inside 'nest' is 'NASTIEST'.
(Other definitions for nastiest that I've seen before include "Most revolting" , "Extremely unpleasant" .)