Most unusual contribution to a mood destroyed (6)
I believe the answer is:
oddest
'most unusual' is the definition.
('odd' can be similar in meaning to 'unusual')
'contribution to a mood destroyed' is the wordplay.
'contribution to' says the answer is hidden in the clue.
'ODDEST' is hidden within 'mood destroyed'.
(Other definitions for oddest that I've seen before include "Strangest" , "Most peculiar or strange" , "Most unusual or uneven" , "Most rum" , "Most eccentric or peculiar" .)