Mostly give comfort to southeast Lancashire? (6)
I believe the answer is:
cheese
'lancashire?' is the definition.
(I've seen this before)
'mostly give comfort to southeast' is the wordplay.
'mostly' means to remove the last letter.
'give comfort to' becomes 'cheer' (I've seen this before).
'southeast' becomes 'SE' (synonyms).
'cheer' with its last letter taken off is 'chee'.
'chee'+'se'='CHEESE'
(Other definitions for cheese that I've seen before include "Stilton eg" , "Nautical cap worn without badge" , "Eg Edam" , "A big one would be important" , "Gloucester or cheddar, say" .)