Mother with "female complaint" (6)
I believe the answer is:
malady
'complaint' is the definition.
(thesaurus)
'mother with female' is the wordplay.
'mother' becomes 'ma' (ma is a kind of mother).
'with' means one lot of letters go next to another.
'female' becomes 'lady' (lady is a kind of female**).
'ma'+'lady'='MALADY'
(Other definitions for malady that I've seen before include "Complaint" , "Ailment; illness" , "Afflication" , "Disease, ailment" , "hay fever, perhaps" .)