Mother with iron disorder -- notice artery (4,4)
I believe the answer is:
main road
'artery' is the definition.
(thesaurus)
'mother with iron disorder notice' is the wordplay.
'mother' becomes 'ma' (ma is a kind of mother).
'with' says to put letters next to each other.
'disorder' indicates an anagram (I've seen 'diseased' mean this (I've seen this in other clues)).
'notice' becomes 'ad'.
'iron' with letters rearranged gives 'inro'.
'ma'+'inro'+'ad'='MAIN ROAD'
(Other definitions for main road that I've seen before include "Radioman found in principal thoroughfare" , "Highway" .)