Mother’s business at last has a talisman (6)
I believe the answer is:
mascot
'a talisman' is the definition.
('mascot' can be a synonym of 'talisman')
'mother's business at last' is the wordplay.
'mother's' becomes 'ma's' (ma can mean mother).
'business' becomes 'co' (short for company).
'last' suggests the final letters.
The final letter of 'at' is 't'.
'mas'+'co'+'t'='MASCOT'
'has' is the link.
(Other definitions for mascot that I've seen before include "Thing supposed to bring good luck" , "Thing believed to bring good luck, perhaps to team" , "Thing believed to bring good luck to, say, team" , "Lucky charm" , "Good-luck item" .)