Mountainous region in central Italy (6)
I believe the answer is:
umbria
'mountainous region in central italy' is the definition.
(I've seen this before)
This is the entire clue.
(Other definitions for umbria that I've seen before include "Mountainous region in central Italy" , "Italian region" , "part of Italy" , "in the Tiber region" , "hilly area of Italy" .)