Mountainous region in central Italy (6)
I believe the answer is:
umbria
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">mountainous region in central italy</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for umbria that I've seen before include "Mountainous region in central Italy" , "Italian region" , "part of Italy" , "in the Tiber region" , "hilly area of Italy" .)