Mouse-like creature playfully tamed? (5)
I believe the answer is:
shrew
This clue is a double definition.
'mouse-like creature' is the first definition.
(I've seen this before)
'playfully tamed?' is the second definition.
(in Shakespeare's play The Taming of the Shrew)
(Other definitions for shrew that I've seen before include "insect eater" , "Scold; insectivore" , "eg Katharina" , "Scold, termagant" , "Little mammal; a scold" .)