Move out with new poison (5)
I believe the answer is:
venom
'poison' is the definition.
(venom is a kind of poison)
'move out with new' is the wordplay.
'out with' indicates anagramming the letters (out can mean wrong or inaccurate).
'new' becomes 'n'.
'move' anagrammed with 'n' makes 'VENOM'.
(Other definitions for venom that I've seen before include "Poisonous secretion" , "ill will" , "acrimony" , "Snake's poison" , "Poisonous liquid of snakes" .)