Move out with new toxin (5)
I believe the answer is:
venom
'toxin' is the definition.
(I know that venom is a type of animal toxin)
'move out with new' is the wordplay.
'out with' is an anagram indicator (out can mean wrong or inaccurate).
'new' becomes 'n' (common abbreviation eg NT for New Testament).
'move' anagrammed with 'n' can make 'VENOM'.
(Other definitions for venom that I've seen before include "Bitter malice" , "Toxic substance" , "ill will" , "acrimony" , "Poisonous secretion" .)