Move to central Acton with a joker companion (6)
I believe the answer is:
twitch
'move' is the definition.
(I know that twitch is a more specific form of move)
'central acton with a joker companion' is the wordplay.
'central' means to look at the middle letters.
'with' is a charade indicator (letters next to each other).
'a joker' becomes 'wit' (a witty person).
'companion' becomes 'ch' (Companion of Honour).
The centre of 'acton' is 't'.
't'+'wit'+'ch'='TWITCH'
'to' acts as a link.
(Other definitions for twitch that I've seen before include "Spasmodic jerk" , "Short sudden jerking movement" , "Pang; small noose" , "Sudden muscular spasm" , "Quiver spasmodically as in tic" .)