Much-changed friend (4)
I believe the answer is:
chum
'friend' is the definition.
(I know that chum is a type of friend)
'much-changed' is the wordplay.
'changed' indicates anagramming the letters.
'much' is an anagram of 'CHUM'.
(Other definitions for chum that I've seen before include "Salmon" , "Close friend (colloq.)" , "Pal, mate" , "Pal, buddy" , "Informally, a close friend" .)