Muck possibly misleads nurses (4)
I believe the answer is:
isle
'muck possibly' is the definition.
(Isle of Muck is an example)
'misleads nurses' is the wordplay.
'nurses' indicates a hidden word (nurse can mean holding closely).
'ISLE' can be found hidden inside 'misleads'.
(Other definitions for isle that I've seen before include "I shall hear" , "Capri or Man, perhaps?" , "Fair ---, knitting style" , "Sea-girt area" , "Ait" .)