Murder in institution probed by yours truly, ahead of CID (8)
I believe the answer is:
homicide
'murder' is the definition.
('homicide' can be a synonym of 'murder')
'institution probed by yours truly ahead of cid' is the wordplay.
'institution' becomes 'home' (home is a kind of institution).
'probed by' indicates putting letters inside (I've seen this in other clues).
'yours truly' becomes 'i'.
'ahead of' says to put letters next to each other (I've seen this in other clues).
'i'+'cid'='icid'
'home' going around 'icid' is 'HOMICIDE'.
'in' acts as a link.
(Other definitions for homicide that I've seen before include "Manslaughter or murder" , "The killing of one person by another" , "Serious crime" , "Murder (mainly US)" , "The killing of one human by another" .)