Music maker at home immersed in red wine (8)
I believe the answer is:
clarinet
'music maker' is the definition.
(clarinet is a kind of musical instrument)
'home immersed in red wine' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in').
'immersed in' indicates putting letters inside.
'red wine' becomes 'claret' (claret is a kind of red wine).
'in' put into 'claret' is 'CLARINET'.
'at' is the link.
(Other definitions for clarinet that I've seen before include "Music-maker" , "Single reed woodwind instrument" , "Single-reed straight-tubed instrument" , "Music maker" , "Blow that!" .)