Musical based on a comic strip (5)
I believe the answer is:
annie
'musical based on a comic strip' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for annie that I've seen before include "Miss Laurie" , "Cartoon strip orphan" , "Sharpshooter Oakley or musical orphan" , "-- Oakley (Wild West)" , "Little Ophan .....; also a musical" .)