Musicians playing in Strand (7)
I believe the answer is:
abandon
'strand' is the definition.
(to abandon someone is to leave them stranded)
'musicians playing' is the wordplay.
'musicians' becomes 'a band' (a musical group).
'playing' becomes 'on' (on can mean playing or performing).
'aband'+'on'='ABANDON'
'in' acts as a link.
(Other definitions for abandon that I've seen before include "Wantonness: desert" , "Stop" , "a complete lack of restraint" , "Completely give up; desert" , "Desert or yield without restraint" .)