My wife, a lady never oddly to give in (5)
I believe the answer is:
yield
'give in' is the definition.
('yield' can be a synonym of 'give in')
I don't understand the remainder of the clue.
Can you help me to learn more?
(Other definitions for yield that I've seen before include "Cede, give way" , "Stop defending" , "Income" , "Submit; produce" , "size of crop" .)