My wife muses this must change (3,6)
I believe the answer is:
the missus
'my wife muses this must change' is the definition.
The definition suggests a singular noun which matches the answer.
'muses this must change' is the wordplay.
'must change' is an anagram indicator (I've seen this in other clues).
'muses'+'this'='musesthis'
'musesthis' is an anagram of 'THE MISSUS'.
Can you help me to learn more?
I've seen this clue in The Independent.
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