Name this setter over something that comes up again (6)
I believe the answer is:
emetic
'something that comes up again' is the definition.
(medicine causing vomiting)
'name this setter over' is the wordplay.
'name' becomes 'cite' (I've seen this in other clues**).
'this setter' becomes 'me' (the setter of the clue).
'over' shows that the letters should be reversed in order.
'cite'+'me'='citeme'
'citeme' backwards is 'EMETIC'.
(Other definitions for emetic that I've seen before include "Medicine designed to induce vomiting" , "Medicine to make you sick" , "making you throw up" , "A medicine to induce nausea" , "Nauseous" .)