Nan leaves in advance of guidance (6)
I believe the answer is:
advice
'guidance' is the definition.
(I've seen this before)
I cannot understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for advice that I've seen before include "Opinion offered as to future action" , "Intelligence" , "tip" , "Recommendation for a course of action" , "Suggestion for appropriate course of action" .)