Nasty in general, almost charged. It's significant (10)
I believe the answer is:
meaningful
'significant' is the definition.
(similar in meaning)
'nasty in general almost charged' is the wordplay.
'nasty in general' becomes 'meaning' (I am not sure about this - if you are sure you should believe this answer much more).
'almost' means to remove the last letter (most of the word but not all of it).
'charged' becomes 'full' (similar in meaning).
'full' with its last letter taken off is 'ful'.
'meaning'+'ful'='MEANINGFUL'
'it's' acts as a link.
Can you help me to learn more?
(Other definitions for meaningful that I've seen before include "Significant" , "Important" .)