Nation starts to ignore reason and question (4)
I believe the answer is:
iraq
'nation' is the definition.
(Iraq is an example)
'starts to ignore reason and question' is the wordplay.
'starts to' indicates taking the first letters.
The initial letters of 'ignore reason and question' is 'IRAQ'.
(Other definitions for iraq that I've seen before include "Mosul's country" , "troubled state" , "In ancient times, it was known as Mesopotamia" , "Country with WMD once?" , "Asian area of conflict" .)