Natural reaction isn't unusual in case of cat (8)
I believe the answer is:
instinct
'natural reaction' is the definition.
'instinct' can be an answer for 'reaction' (I have seen 'Innate reaction' mean 'instinct' so perhaps 'reaction' could also mean 'instinct'). I am not certain of the 'natural' bit.
'isn't unusual in case of cat' is the wordplay.
'unusual' is an anagram indicator.
'case of' says to hollow out the word (remove centre letters) (outsides of).
'cat' with its middle taken out is 'ct'.
'isnt' anagrammed gives 'inst'.
'inst'+'in'+'ct'='INSTINCT'
Can you help me to learn more?
(Other definitions for instinct that I've seen before include "Natural inclination" , "Natural response" , "Inborn impulse to behave in certain way" , "Gut feeling" , "Natural aptitude" .)