Nature’s advancing onset of catastrophe in response (8)
I believe the answer is:
creation
'nature's' is the definition.
(synonyms)
'advancing onset of catastrophe in response' is the wordplay.
I cannot really see how this works, but
'of' could be 'o' and 'o' is located in the answer.
'in' is within the answer.
This may be the basis of clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for creation that I've seen before include "A thing made or invented" , "Life, the universe and everything" , "The bringing into existence of something" , "Dawn of time" , "Beginning event" .)