Ned's out to upset the famous! (5)
I believe the answer is:
noted
'famous' is the definition.
(noted can mean well-known or famous)
'ned's out to upset' is the wordplay.
'out' means one lot of letters goes inside another.
'upset' is a reversal indicator.
'to' in reverse letter order is 'ot'.
'ned' enclosing 'ot' is 'NOTED'.
'the' is the link.
(Other definitions for noted that I've seen before include "Remarked - famous" , "Illustrious" , "prominent" , "Wrote it down" , "Like music" .)