Needlewoman holding end of thick pin (6)
I believe the answer is:
skewer
'pin' is the definition.
(skewer is a kind of pin)
'needlewoman holding end of thick' is the wordplay.
'needlewoman' becomes 'sewer' (I've seen this before).
'holding' indicates putting letters inside.
'end of' says to take the final letters.
The last letter of 'thick' is 'k'.
'sewer' enclosing 'k' is 'SKEWER'.
(Other definitions for skewer that I've seen before include "Run through" , "Meat-securing pin" , "Pin used in cooking" , "Pin for roasts" , "Metal spit" .)