Needleworker cheers dry reaction to double entendre? (8)
I believe the answer is:
tattooer
'needleworker' is the definition.
'cheers dry reaction to double entendre?' is the wordplay.
'cheers' becomes 'ta' (I've seen this in other clues).
'dry' becomes 'tt' (abbreviation for teetotal).
'reaction to double entendre?' becomes 'ooer' (exclamation in response to a sexual comment).
'ta'+'tt'+'ooer'='TATTOOER'
(Other definitions for tattooer that I've seen before include "One working with needle" , "Designer" , "One puts designs on skin" , "he may get under your skin" , "colourful skin marker" .)