Nervous crone in tragedy, gutless (7)
I believe the answer is:
twitchy
'nervous' is the definition.
(I've seen this before)
'crone in tragedy gutless' is the wordplay.
'crone' becomes 'witch' (synonyms).
'in' means one lot of letters goes inside another.
'gutless' means to remove the middle letters.
'tragedy' with its middle taken out is 'ty'.
'witch' placed inside 'ty' is 'TWITCHY'.
(Other definitions for twitchy that I've seen before include "in a stew" , "Showing signs of nervousness" , "Agitated" , "Nervous" , "Jerky" .)