Never mind 50% of design or start of explanation (6)
I believe the answer is:
ignore
'never mind' is the definition.
'ignore' can be an answer for 'mind' (thesaurus). I am not sure about the 'never' bit.
'50% of design or start of explanation' is the wordplay.
'50% of' indicates taking half.
'start of' suggests taking the first letters.
The first letter of 'explanation' is 'e'.
'design' cut in half is 'ign'.
'ign'+'or'+'e'='IGNORE'
Can you help me to learn more?
(Other definitions for ignore that I've seen before include "Deliberately overlook" , "Neglect" , "Forget" , "Walk away from" , "Region in which to snub" .)