New shrine ultimately south of a European river (7)
I believe the answer is:
rhenish
'of a european river' is the definition.
(I've seen this before)
'new shrine ultimately south' is the wordplay.
'new' indicates anagramming the letters.
'ultimately' suggests the final letters.
The last letter of 'south' is 'h'.
'shrine' with letters rearranged gives 'rhenis'.
'rhenis'+'h'='RHENISH'
(Other definitions for rhenish that I've seen before include "Herein's Schumann's Third" , "white wine" , "Hock - relating to a European river" , "as a European banker" , "- - Wine (hock)" .)