New shrine ultimately south of a European river (7)
I believe the answer is:
rhenish
'of a european river' is the definition.
(I've seen this before)
'new shrine ultimately south' is the wordplay.
'new' indicates an anagram.
'ultimately' says to take the final letters.
The final letter of 'south' is 'h'.
'shrine' is an anagram of 'rhenis'.
'rhenis'+'h'='RHENISH'
(Other definitions for rhenish that I've seen before include "Herein's Schumann's Third" , "white wine" , "Hock - relating to a European river" , "as a European banker" , "- - Wine (hock)" .)