New team not beginning to react? It makes no difference (2,6)
I believe the answer is:
no matter
'it makes no difference' is the definition.
(I've seen this before)
'new team not beginning to react?' is the wordplay.
'new' indicates an anagram.
'beginning to' says to take the initial letters.
The first letter of 'react' is 'r'.
'team'+'not'='teamnot'
'teamnot' is an anagram of 'nomatte'.
'nomatte'+'r'='NO MATTER'
(Other definitions for no matter that I've seen before include "It makes no difference" , "Forget it!" , "Never mind" , "It's not important - what a torment" , "Don't mind" .)