Nibble with drunken panache, leaving hotel (6)
I believe the answer is:
canape
'nibble' is the definition.
(I have seen 'Savoury nibble' mean 'canape' so perhaps 'nibble' could also mean 'canape')
'drunken panache leaving hotel' is the wordplay.
'drunken' indicates an anagram.
'leaving' is a deletion indicator.
'hotel' becomes 'h' (phonetic alphabet).
'panache' with 'h' taken away is 'panace'.
'panace' is an anagram of 'CANAPE'.
'with' is the link.
(Other definitions for canape that I've seen before include "Small appetiser" , "Small biscuit with savoury on top" , "Party nibble" , "part of a buffet?" , "Piece of finger-food" .)