Crossword Genius

Nick run down on vacation (5,3)

Ross

I believe the answer is:

knock off

'nick' is the definition.

'run down on vacation' is the wordplay.
'run down' becomes 'knock' (both can mean to criticise or disparage**).
'on vacation' becomes 'off' (off can mean away on holiday).
'knock'+'off'='KNOCK-OFF'

(Other definitions for knock off that I've seen before include "call it a day" , "Stop work (informal)" , "finish work" , "Down tools" , "half-inch > pack in work" .)

I've seen this clue in The Guardian.
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