No 1 from Adele, originally by Queen (6)
I believe the answer is:
leader
'no 1' is the definition.
'adele originally by queen' is the wordplay.
'originally' indicates anagramming the letters.
'by' means one lot of letters go next to another.
'queen' becomes 'r' (r is abbreviation regina. e.g. in ER ).
'adele' is an anagram of 'leade'.
'leade'+'r'='LEADER'
'from' acts as a link.
(Other definitions for leader that I've seen before include "One is ahead and shows the way" , "Boss, commander" , "important member of orchestra" , "Pioneer" , "Party head" .)