No ale is made without help (5)
I believe the answer is:
alone
'without help' is the definition.
(I've seen this in another clue)
'no ale is made' is the wordplay.
'is made' indicates anagramming the letters.
'no'+'ale'='noale'
'noale' with letters rearranged gives 'ALONE'.
(Other definitions for alone that I've seen before include "Without others being involved" , "Lacking company, solitary" , "Isolated; exclusively" , "Solo" , "Without others present" .)