No friend from Yemen (5)
I believe the answer is:
enemy
'no friend' is the definition.
(I've seen this in another clue)
'from yemen' is the wordplay.
'from' indicates anagramming the letters (from the letters).
'yemen' is an anagram of 'ENEMY'.
(Other definitions for enemy that I've seen before include "Yemen (anag.)" , "is against us" , "Hostile opponent" , "Hostile person, foe" , "Division" .)