No real cowboy strikes a false note (4)
I believe the answer is:
dude
'cowboy strikes a false note' is the definition.
I can't tell whether this definition defines the answer.
'no real' is the wordplay.
'no' becomes 'dud' (I can't justify this - if you can you should believe this answer much more).
'real' becomes 'e' (e is a kind of real).
'dud'+'e'='DUDE'
Can you help me to learn more?
(Other definitions for dude that I've seen before include "He's no cowboy" , "American bloke" , "Stylish and affected man" , "Man (American slang)" , "A (dandy) American city dweller" .)