No way out around the centre at least (6)
I believe the answer is:
anyhow
'at least' is the definition.
(synonyms)
'no way out around the centre' is the wordplay.
'out' indicates an anagram (out can mean wrong or inaccurate).
'around' is an insertion indicator.
'centre' says to take the centre.
The centre of 'the' is 'h'.
'no'+'way'='noway'
'noway' anagrammed gives 'anyow'.
'anyow' going around 'h' is 'ANYHOW'.
(Other definitions for anyhow that I've seen before include "In spite of what has been said" , "Not in an orderly manner, by whatever means" , "In whatever case" , "In a haphazard manner" , "No matter what" .)