No-hoper’s new role picking up seaweed at front (5)
I believe the answer is:
loser
'no-hoper's' is the definition.
(I've seen this before)
'new role picking up seaweed at front' is the wordplay.
'new' indicates anagramming the letters.
'picking up' is an insertion indicator.
'at front' says to take the initial letters.
The initial letter of 'seaweed' is 's'.
'role' anagrammed gives 'loer'.
'loer' enclosing 's' is 'LOSER'.
(Other definitions for loser that I've seen before include "Proverbially, one who hesitates" , "Roles for the defeated" , "Defeated competitor" , "Non-achiever" , "Unsuccessful type" .)