Not against a professional (3)
I believe the answer is:
pro
'professional' is the definition.
(abbreviation)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for pro that I've seen before include "Favouring the professional" , "Professional; advantage" , "Paid worker" , "Of argument, say, in favour of" , "For; non-amateur" .)