Not at home, on job in remote settlement (7)
I believe the answer is:
outpost
'remote settlement' is the definition.
(I've seen this before)
'not at home on job' is the wordplay.
'not at home' becomes 'out' (out can mean away from home).
'on' is a charade indicator (letters next to each other) (in a down clue, letters appear on others).
'job' becomes 'post' (post is a kind of job).
'out'+'post'='OUTPOST'
'in' acts as a link.
(Other definitions for outpost that I've seen before include "Remote settlement" , "Remote branch" , "Remote part of the country" , "distant location" , "Outlying settlement" .)